Side Effects Of Moderna's COVID-19 Booster Shot Explained

In late October, the CDC expanded eligibility for Moderna's COVID-19 booster shot (via Centers for Disease Control and Prevention). Certain individuals may receive a booster shot six months after finishing their initial two doses. People who are eligible for a Moderna booster shot include those who are 65 years or older, and those who are 18 years or older and live in long-term care settings, have underlying medical conditions, or work or live in high-risk settings.

Underlying medical conditions include health issues that may put you at a higher risk of developing COVID-19 or may make it more difficult for your body to fight off the disease. Some of these conditions include cancer, chronic lung disease, and diabetes, although the full list is extensive (via CDC). If you are unsure whether or not you should get a COVID-19 booster shot due to an underlying health condition, speak to your doctor about it. High-risk work settings that may make you eligible for a booster shot include, but are not limited to, first responders, education staff, public transit workers, and grocery store workers.

Moderna's COVID-19 booster shot side effects are similar to second dose

According to AARP, Moderna's COVID-19 booster shot contains half the dose of the shot used in the primary series. Although the dose is smaller, the side effects seem to be similar to those seen after the second Moderna dose. Based on data taken by Moderna, the most common side effects of the booster shot include injection site pain, fatigue, headache, muscle pain, and joint pain. Chills, nausea, and vomiting have also been reported. Symptoms seem to be worse in recipients ages 18 to 64 and not as severe for those over the age of 65.

However, data from Israel's booster shot program indicate that symptoms are less severe overall after getting the booster shot than they were during the initial shots. Fewer side effects have been reported for both the Pfizer and Johnson & Johnson vaccines and experts expect the same data to follow with the Moderna booster shot. According to Robert Weber, administrator for pharmacy services at the Ohio State University Wexner Medical Center, who has been administering Pfizer and Moderna booster shots in recent weeks, "many, if not all of [the recipients], are experiencing zero to very minor mild-to-moderate side effects."

Previous experience with the COVID-19 vaccine may help

Moderna's COVID-19 booster shot side effects may be less severe because the dose is smaller, but it may also be because people are more prepared for the experience. According to Robert Weber, administrator for pharmacy services at the Ohio State University Wexner Medical Center, people who are getting the booster shot know what to expect and how to prepare this time around (via AARP). "I think people also understand how to manage the side effects better in terms of drinking plenty of water prior to getting a vaccine, drinking plenty of water after you get the vaccine, taking it easy the next day," he said.

Being less nervous about receiving the COVID-19 booster may also prevent symptoms like anxiety, which can make other symptoms feel worse or more concerning. AARP also noted that health officials have said it is okay to get a booster shot from a different brand. If your symptoms were particularly uncomfortable from Moderna's first two doses, for example, you may be able to get a Pfizer booster shot instead.

Vaccine side effects are common

Although experiencing side effects from a vaccine can be nerve-wracking, mild to moderate symptoms are very common. According to the CDC, your body creates an immune response to the vaccine that will protect you in the future. If the disease you are being vaccinated for ever enters your body, your immune system will be prepared to fight it. Mild side effects, including injection site pain, fatigue, headache, muscle pain, and joint pain, are all extremely common. You shouldn't worry if you experience those effects after receiving Moderna's COVID-19 booster shot.

Some people are concerned about long-term side effects, but experts say these are rare. According to Women's Health, most side effects occur within a few days or weeks of receiving a vaccine or booster. "Thinking of all the vaccines we use in childhood and adulthood, I can't think of any long-term side effects," said William Schaffner, MD, an infectious disease specialist and professor at the Vanderbilt University School of Medicine. "Vaccines don't have a bad effect that occurs eight months, a year or two, or longer." All vaccines and boosters, including the ones developed for COVID-19, go through a rigorous testing and approval process through the FDA before they are authorized for public use.

Why are booster shots needed?

Regardless of how effective a vaccine is, its efficacy can wear off over time. This has been the case with the COVID-19 vaccines, as well as many other vaccines in our history. According to GoodRX, childhood vaccines like DTaP (diphtheria, tetanus, pertussis) require a booster shot after the protection from the initial shot decreases over time. The prevalence of new COVID-19 variants also affects the initial vaccine's efficacy. The antibodies we create after our first doses may not be as effective at fighting these variants, and a booster shot can make sure we are better protected.

So far, the Pfizer and Moderna vaccines have been highly effective against the various COVID-19 variants that have emerged. If you are eligible for a booster shot, getting one can significantly reduce your risk of developing COVID-19. It seems that booster shots will become available for all Americans eventually. Depending on how well the vaccines protect us in the long-term, the COVID-19 vaccine may require a yearly booster shot like the flu.

Getting vaccinated offers better protection than natural immunity

The CDC released a new study on October 29th that shows that vaccination against COVID-19 offers better protection against the virus than a previous infection (via CDC). Previously, some people had argued that the antibodies created during a COVID-19 infection were better equipped to fight an additional COVID-19 infection. The CDC's new science, however, disputes this claim, stating that after observing 7,000 people across nine states who were hospitalized with COVID-19 symptoms, "those who were unvaccinated and had a recent infection were 5 times more likely to have COVID-19 than those who were recently fully vaccinated and did not have a prior infection."

These findings show that "vaccination can provide a higher, more robust, and more consistent level of immunity to protect people from hospitalization for COVID-19 than infection alone." If you have already been vaccinated, a COVID-19 booster shot can increase your level of protection. If you are not currently eligible for a COVID-19 booster shot, keep any eye out for updated eligibility requirements.