Celebs Who Dealt With 'Ozempic Face' From GLP-1 Use In 2025

Weight loss drugs that fall under the category of glycogen-like peptide-1 (GLP-1) agonists (e.g., Ozempic, Wegovy, Mounjaro) have steadily increased in popularity. In fact, a 2025 survey conducted by KFF showed that 18% of adults said they were either using or had used a GLP-1 for weight loss or diabetes.

GLP-1s have the ability to reduce hunger cravings and regulate sugar levels within a few days. As a result, individuals who take GLP-1s tend to lose weight quickly after the medication begins taking hold, which happens in a few days to a couple of weeks (via Mayo Clinic).

While losing weight predictably may sound like a dream come true, GLP-1s like Ozempic can carry unintended side effects. Perhaps the most obvious is the loss of body fat everywhere, including around the cheeks and jaw, spurring the term "Ozempic face." Cosmetic surgery expert Dr. Joshua Zeichner explained the phenomenon to Prevention: "Weight loss, whether it is from diet, exercise, surgery, or a medication, takes a toll on your face."

For many people not in the public eye, having a gaunt, hollow "Ozempic face" may not be a big deal. However, celebs tend to be photographed often, which puts their GLP-1 symptom front and center as fans express their surprise (and sometimes their concern). And there were certainly many famous faces that changed in 2025 due to GLP-1s.

The mother-daughter duo of Sharon and Kelly Osbourne have been in the spotlight for decades. In 2025, though, they got press not for their talents but for their smaller silhouettes, including their unrecognizable faces. At least one individual noted on X that Kelly might be mistaken for her mother, writing, "She looks 70."

Kelly, who previously underwent a bariatric surgery procedure that caused a head-turning weight loss at the time, went on social media in response to criticisms about her frame (via Entertainment Tonight). In the post, she blamed her current drop in weight on being unable to eat after the death of her father, legendary musician Ozzy Osbourne. Additionally, she hasn't admitted to taking a GLP-1; instead, she's merely gone on record to say that she supports others who do. Consequently, her "Ozempic face" might genuinely be caused by other weight loss strategies and her personal grief.

Sharon, on the other hand, has admitted that she went "too far" with Ozempic on the "Howie Mandel Does Stuff" podcast. During her interview, she explained that she probably wouldn't be able to gain weight again and couldn't undergo cosmetic treatments (like fillers and surgeries) to improve the fullness of her face.

Losing weight was always difficult for performer Whoopi Goldberg, who said while on "The Kelly Clarkson Show" in 2024 that after reaching 300 pounds, she turned to Mounjaro. Dished Goldberg, "I'm doing that wonderful shot that works for folks who need some help and it's been really good for me." (Read about Whoopi Goldberg's nerve pain condition.)

By 2025, Goldberg seemed to be sporting a case of "Ozempic face," at least in the eyes of dermatologist Dr. Michele Green (via the Daily Mail). Dr. Green identified Goldberg, among many other Hollywood "Who's Who" figures, as having the telltale visual signs left by GLP-1s. "Many users of Ozempic who I know report noticeable volume loss in the face, which can result in the formation of fine lines, wrinkles, sagging skin, and jowls around the mouth."

During Goldberg's appearance on Clarkson's show, Clarkson said she had used drugs as well to lose stubborn weight. However, she was quick to say that the medication wasn't Ozempic, although she described it as being one that aids in sugar processing (via ABC News).

After catapulting to fame on "Queer Eye," hairstylist Jonathan Van Ness confessed via TikTok in 2025 that his binge-eating disorder had grown out of control. To rectify his eating, he tried a GLP-1 after getting advice and the green light from his physician.

Van Ness has been positive about his GLP-1 results, even showing off his abs in a 2025 Instagram post. Nonetheless, some fans reacted to his post in alarm, with one stating, "Now you need to stop," and another warning, "Drop the wellness routine!"

Could Van Ness or any other GLP-1 user actually be in danger of dipping too low on the scale? Yes, according to a 2025 article in Obesity Reviews. The article claims that unmonitored use of GLP-1s can potentially lead to the "development or exacerbation of restrictive eating behaviors." Constant doctor screening and patient assessment during GLP-1 treatment can mitigate this possibility, though. (Here are some things you might not know about eating disorders.)

If you need help with an eating disorder, or know someone who does, help is available. Visit the National Eating Disorders Association website or contact NEDA's Live Helpline at 1-800-931-2237. You can also receive 24/7 Crisis Support via text (send NEDA to 741-741).