How Much Weight Has Oprah Winfrey Lost On Ozempic? This Side-By-Side Pic Says It All

At 72, Oprah Winfrey's legendary career in show business has often centered around an unfair topic: her weight. She once told People she'd been historically "blamed and shamed" for her fluctuating size. (Per the star, 211 pounds is the lower limit of her body's "genetically-influenced weight range," or her "enough point.") But today, her frame is taking a positive center stage as she debuts both a new book, "Enough," and a major late-life weight loss transformation with the help of a GLP-1 drug.

Matt Winkelmeyer/Getty Images & Neil Mockford/GC Images

A recent side-by-side pic of Winfrey in 2022 versus 2026 highlights just how much she's trimmed down since beginning to take GLP-1s in 2023. According to a 2025 interview with Jane Pauley for CBS News, she's brought her weight down to around 155 pounds. However, her journey to overcoming obesity in her senior years reveals several key facts about the way GLP-1s work.

First is that GLP-1s can be safe for adults who are in their 70s, like Winfrey. (Many celebrities over 50 have used GLP-1s.) According to geriatrician Dr. Chitra Ganta in an article for the American Academy of Medical Colleges (AAMC), she is careful when prescribing GLP-1s for patients older than 65.

That said, Dr. Ganta feels that since a large percentage of seniors are obese, offering them the chance to try GLP-1s can improve their health. In the same AAMC piece, Dr. John Batsis admitted that he wasn't a fan of giving GLP-1s to older patients but has softened his views to a simple dosing philosophy based on current evidence that the drugs may offer help: "Start low, and go slow."

In fact, "low and slow" is the same advice that Winfrey's "Enough" co-author, endocrinologist Dr. Ania Jastreboff, shared while visiting the TODAY Show with the star. "If you're feeling nauseated, then don't increase the dose," she said.

Indeed, Winfrey did feel a major side effect from GLP-1s, but it wasn't nausea. Instead, she experienced constipation, another commonly reported effect from GLP-1s. On TODAY, Winfrey explained that she drinks a gallon of water and takes magnesium to keep her bowels moving.

Winfrey made another important discovery about GLP-1s since starting them three years ago: They don't protect you against weight gain. While a guest on the podcast "Wild Card with Rachel Martin," Winfrey noted, "Well, when I turned 70, I decided, OK, I've gotten to the weight. I think I can hold this weight if I just continue to eat less, eat all my meals by 4 o'clock, continue hiking, continue doing all the things." Winfrey discontinued using her GLP-1 and gradually regained 20 pounds. At that point, she decided to go back on the drug and stay on it as a way to maintain her new figure and lifestyle.